Some viruses produce insulin-like hormones that can stimulate human cells — and have potential to cause disease

http://ift.tt/2EDIgHN Scientists have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer.

Advertisements

How the insulin receptor works

http://ift.tt/2EEh8Ey As we are approaching the 100th anniversary of the discovery of insulin, a wide array of its signaling pathways has been defined. However, the initial step in insulin action, i.e. the engagement with its cell-surface receptor and the resulting conformational change, which propagates across the plasma membrane to the intracellular module, remains poorly understood.

While a baby was still attached via the umbilical cord, doctors attached a pacemaker to the baby’s heart

http://ift.tt/2o6PsC0 Researchers completed the first-ever EXIT (Ex Utero Intrapartum Treatment) to ventricular pacing procedure. The patient, a 36-week fetus with complete atrioventricular block and cardiac dysfunction, was at high risk of pre-term death. While attached to its mother via umbilical cord, the baby received a temporary pacemaker, which stabilized its dangerously low and irregular heart rate and ensured enough blood flow from the heart to the rest of its body for delivery.

Hearing loss is common after infant heart surgery

http://ift.tt/2HkQOku Children who have heart surgery as infants are at risk for hearing loss, coupled with associated risks for language, attention and cognitive problems, by age four. In a cohort of 348 preschoolers who survived cardiac surgery, researchers found hearing loss in about 21 percent, a rate 20 times higher than is found in the general population. This underscores the importance of early hearing evaluations in young children who undergo heart surgery.