Mothers of women with polycystic ovary syndrome have increased risk of early death Mothers of daughters with polycystic ovary syndrome (PCOS) have a significantly increased risk of death, particularly if they also have diabetes, when compared to the general population, according to new research. The researchers found that mothers aged over 60 had a risk of death that was one-and-a-half times greater than the general population. When compared with a control group of women with type 2 diabetes from the general population, diabetic mothers of PCOS daughters had a two-fold increased risk of death.

Depression, early death among seniors with diabetes: Strong link found by research Depression is linked with a far greater chance for early death among adults 65 and older with diabetes compared with people of the same age who do not have depression, research shows. The researchers suggest that the higher mortality rate among those with depression could stem from the fact that depressed people are less likely than their non-depressed counterparts to adhere to their prescribed medications, diet, exercise and glucose self-monitoring.

Dangers of chemotherapy regimen for bladder cancer patients uncovered by clinical trial Patients with muscle-invasive bladder cancer often benefit from chemotherapy before surgery to remove the tumor, but a test of one regimen by researchers was halted when too many people experienced serious side effects such as heart attacks and blood clots in the legs and lungs.

Gene expression signature identifies patients at higher risk for cardiovascular death A gene expression profile associated with an elevated risk of cardiovascular death has been identified by a study of 338 patients with coronary artery disease. Used with other indicators such as biochemical markers and family history, the profile — based on a simple blood test — may help identify patients who could benefit from personalized treatment and counseling designed to address risk factors.

Improvements in blood pressure control may have prevented hundreds of thousands of major cardiovascular events Hypertension (raised blood pressure) treatment rates have almost doubled and control rates have tripled in England between 1994 and 2011, resulting in the saving of tens of thousands of lives each year, according to a new study. The findings also suggest that if these improvements in blood pressure management continue until 2022, 80% of patients being treated for hypertension will have achieved control of their high blood pressure, preventing a further 50,000 major cardiovascular events (eg, strokes, heart attacks, and deaths) in that year.

Systolic, diastolic blood pressures predict risk of different cardiovascular diseases Raised systolic and diastolic blood pressures may have different effects on different types of cardiovascular diseases and at different ages, according to new research involving 1.25 million patients from primary care practices. The new findings suggest that individuals with higher systolic blood pressures have a greater risk of intracerebral haemorrhage (stroke caused by bleeding within the brain tissue), subarachnoid haemorrhage (the deadliest form of stroke), and stable angina, whereas raised diastolic blood pressure is a better indicator of abdominal aortic aneurysm risk.

Quantity, not quality: Risk of sudden cardiac death tied to protein overproduction A genetic variant linked to sudden cardiac death leads to protein overproduction in heart cells, scientists report. Unlike many known disease-linked variants, this one lies not in a gene but in so-called noncoding DNA, a growing focus of disease research. The discovery also adds to scientific understanding of the causes of sudden cardiac death and of possible ways to prevent it, the researchers say.